参考文献

[1]ZHANG J,CAO L J,HONG W,et al. Ginsenosides regulate PXR/NF-κB signaling and attenuate dextran sulfate sodium-induced colitis[J].Drug Metab Dispos,2015,43(8):1181-1189.

[2]LI H F,Xiao J C,LI X N,et al. Low Cerebral exposure cannot hinder the neuroprotective effects of panax notoginsenosides[J].Drug Metab Dispos,2018,46(1):53-65.

[3]ZHENG X,MA S J,KANG A,et al. Chemical dampening of Ly6Chimonocytes in the periphery produces anti-depressant effects in mice[J].Sci Rep,2016,6:19406.

[4]XIAO J C,CHEN H M,KANG D,et al. Qualitatively and quantitatively investigating the regulation of intestinal microbiota on the metabolism of panax notoginseng saponins[J].J Ethnopharmacol,2016,194:324-336.

[5]CUI S,PAN X J,GE C L,et al. Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor alpha[J].Chin J Nat Med,2021,19(6):401-411.

[6]CAO G,WANG N,HE D,et al. Intestinal mucosal metabolites-guided detection of trace-level ginkgo biloba extract metabolome[J].J Chromatogr A,2019,1608:460417.

[7]YAN T T,WANG H,CAO L J,et al. Glycyrrhizin alleviates nonalcoholic steatohepatitis via modulating bile acids and meta-inflammation[J].Drug Metab Dispos,2018,46(9):1310-1319.

[8]YAN T T,WANG H,ZHAO M,et al. Glycyrrhizin protects against acetaminophen-induced acute liver injury via alleviating tumor necrosis factor alpha-mediated apoptosis[J].Drug Metab Dispos,2016,44(5):720-731.

[9]FAN Q,GUAN X,HOU Y,et al. Paeoniflorin modulates gut microbial production of indole-3-lactate and epithelial autophagy to alleviate colitis in mice[J].Phytomedicine,2020,79:153345.

[10]WANG Y,WU J W,ZHU J Y,et al. Ginsenosides regulation of lysophosphatidylcholine profiles underlies the mechanism of Shengmai Yin in attenuating atherosclerosis[J].J Ethnopharmacol,2021,277:114223.

[11]ZHONG C,JIANG C,NI S,et al. Identification of bioactive anti-angiogenic components targeting tumor endothelial cells in Shenmai injection using multidimensional pharmacokinetics[J].Acta Pharm Sin B,2020,10(9):1694-1708.

[12]CHENG L,LIU W,ZHONG C,et al. Remodeling the homeostasis of pro- and anti-angiogenic factors by Shenmai injection to normalize tumor vasculature for enhanced cancer chemotherapy[J].J Ethnopharmacol,2021,270:113770.

[13]HU J,HUANG H,CHE Y,et al. Qingchang Huashi formula attenuates DSS-induced colitis in mice by restoring gut microbiota-metabolism homeostasis and goblet cell function[J].J Ethnopharmacol,2021,266:113394.

[14]HAO H P,ZHENG X,WANG G J.Insights into drug discovery from natural medicines using reverse pharmacokinetics[J].Trends Pharmacol Sci,2014,35(4):168-177.

[15]SUN R B,KONG B,YANG N,et al. The Hypoglycemic effect of berberine and berberrubine involves modulation of intestinalFXR Signaling pathway and inhibition of hepatic gluconeogenesis[J].Drug Metab Dispos,2021,49(3):279-286.

[16]RAFFAELLI A,SABA A,VIGNALI E,et al. Direct determination of the ratio of tetrahydrocortisol+allo-tetrahydrocortisol to tetrahydrocortisone in urine by LC-MS-MS[J].J Chromatogr B Analyt Technol Biomed Life Sci,2006,830(2):278-285.

[17]FAN Q L,GUAN X J,HOU Y L,et al. Paeoniflorin modulates gut microbial production of indole-3-lactate and epithelial autophagy to alleviate colitis in mice[J].Phytomedicine,2020,79:153345.

[18]FEI F,AA L X,QI Q,et al. Paeoniflorin inhibits Th1 and Th17 cells in gut-associated lymphoid tissues to produce anti-arthritis activities[J].Inflammo pharmacology,2019,27(6):1193-1203.

[19]KANG A,HAO H P,ZHENG X,et al. Peripheral anti-inflammatory effects explain the ginsenosides paradox between poor brain distribution and anti-depression efficacy[J].J Neuroinflammation,2011,8:100.

[20]ZANG X J,ZHENG X,HOU Y L,et al. Regulation of proinflammatory monocyte activation by the kynurenine-AhR axis underlies immunometabolic control of depressive behavior in mice[J].FASEB J,2018,32(4):1944-1956.

[21]ZHENG X,HU M M,ZANG X J,et al. Kynurenic acid/GPR35axis restricts NLRP3inflammasome activation and exacerbates colitis in mice with social stress[J].Brain Behav Immun,2019,79:244-255.

[22]HAO H P,CAO L J,JIANG C T,et al. Farnesoid X receptor regulation of the NLRP3inflammasome underlies cholestasis-associated sepsis[J].Cell Metab,2017,25(4):856-867,e5.

[23]汪小莉,刘晓,韩燕全,等.中药药效物质基础主要研究方法概述[J].中草药,2018,49(4):941-947.

[24]YE H,WANG L,ZHU L,et al. Stepped collisional energy MS(All):an analytical approach for optimal MS/MS acquisition of complex mixture with diverse physicochemical properties[J].J Mass Spectrom,2016,51(5):328-341.

[25]WU L,WU Y Z,SHEN H Y,et al. Quantitative structure-ion intensity relationship strategy to the prediction of absolute levels without authentic standards[J].Anal Chim Acta,2013,794:67-75.

[26]YE H,ZHU L,WANG L,et al. Stepped MS(All)Relied Transition(SMART):An approach to rapidly determine optimal multiple reaction monitoring mass spectrometry parameters for small molecules[J].Anal Chim Acta,2016,907:60-68.

[27]ZHENG X,KANG A,DAI C,et al. Quantitative analysis of neurochemical panel in rat brain and plasma by liquid chromatography-tandem mass spectrometry[J].Anal Chem,2012,84(22):10044-10051.

[28]ZHU M L,XU X W,HOU Y L,et al. Boronic derivatization of monoacylglycerol and monitoring in biofluids[J].Anal Chem,2019,91(10):6724-6729.

[29]WANG L,YE H,SUN D,et al. Metabolic pathway extension approach for metabolomic biomarker identification[J].Anal Chem,2017,89(2):1229-1237.

[30]HOU Y L,HE D D,YE L,et al. An improved detection and identification strategy for untargeted metabolomics based on UPLC-MS[J].J Pharm Biomed Anal,2020,191:113531.

[31]ZHENG Q L,TIAN Y,RUAN X J,et al. Probing specific ligand-protein interactions by native-denatured exchange mass spectrometry[J].Anal Chim Acta,2018,1036:58-65.

[32]ZHENG Q,RUAN X,TIAN Y,et al. Ligand-protein target screening from cell matrices using reactive desorption electrospray ionization-mass spectrometry via a native-denatured exchange approach[J].Analyst,2019,144(2):512-520.

[33]TIAN Y,BAO Q,WANG N,et al. Time-resolved acetaldehyde-based accessibility profiling maps ligand-target interactions[J].J Am Soc Mass Spectrom,2021,32(2):519-530.